Machine-written from the fields above · claude-haiku-4-5-20251001
The Drug Enforcement Administration published a notice on an application by Sigma Aldrich Research Biochemicals, Inc. to register as a bulk manufacturer of controlled substances.
The Drug Enforcement Administration published a notice on an application by Sigma Aldrich Research Biochemicals, Inc. to register as a bulk manufacturer of controlled substances. — via Downstream, https://downstream.sh/daily/agency/drug-enforcement-administration/#s-2026-10-29
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NoticeJustice DepartmentDrug Enforcement Administration
Sigma Aldrich Research Biochemicals, Inc. has applied to be registered as a bulk manufacturer of basic class(es) of controlled substance(s). Refer to SUPPLEMENTARY INFORMATION listed below for further drug information.
- ○Comments close in 60 days
91 FR 68166FR Doc. 2026-22048official PDF↗federalregister.gov↗
Machine-written from the fields above · claude-haiku-4-5-20251001
The DEA published two proposed rules to schedule hydroxymitragynine-related substances and one notice regarding a practitioner decision.
The DEA published two proposed rules to schedule hydroxymitragynine-related substances and one notice regarding a practitioner decision. — via Downstream, https://downstream.sh/daily/agency/drug-enforcement-administration/#s-2026-10-14
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Proposed RuleJustice DepartmentDrug Enforcement Administration
The Administrator of the Drug Enforcement Administration (DEA) is issuing this notice of intent to publish a temporary order to schedule 7-hydroxymitragynine and mitragynine pseudoindoxyl (including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible) when either substance alone, or their combined amount if both are present, is above a specified threshold, in schedule I of the Controlled Substances Act (CSA). Based on a different threshold provided by the Department of Health and Human Services (HHS) in July of 2025, DEA published a notice of intent to temporarily schedule 7-hydroxymitragynine above that lower threshold on July 7, 2026. Additionally, DEA published a temporary order placing mitragynine pseudoindoxyl without a threshold in schedule I of the CSA on August 26, 2026. On October 8, 2026, HHS sent a letter recommending that DEA place of the CSA 7-hydroxymitragynine and mitragynine pseudoindoxyl in schedule I when either substance alone, or their combined amount if both are present, is above a new specified threshold. Based on the October 8, 2026 letter, DEA is issuing this notice of intent. While the new threshold recommended by HHS would permit certain products to remain in the marketplace without being subject to schedule I controls, neither HHS nor DEA has made a finding that these substances are safe to use at below-threshold levels. When a temporary order is issued, it will impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle 7- hydroxymitragynine and/or mitragynine pseudoindoxyl above the specified threshold. In a separate document contained in this issue of the Federal Register, DEA is withdrawing the July 7, 2026 notice of intent related to 7-hydroxymitragynine. The August 26, 2026 temporary order placing mitragynine pseudoindoxyl in schedule I of the CSA without a threshold remains in effect until either it expires or the new temporary order is published and the previous order is withdrawn, whichever occurs first.
91 FR 65370FR Doc. 2026-20943official PDF↗federalregister.gov↗
Proposed RuleJustice DepartmentDrug Enforcement Administration
The Drug Enforcement Administration (DEA) is issuing this notice of intent to publish a temporary order to schedule two 7- hydroxymitragynine-related substances (MGM-15 and MGM-16), including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible, in schedule I of the Controlled Substances Act (CSA). On August 26, 2026, DEA published a temporary order placing mitragynine pseudoindoxyl, MGM-15, and MGM-16 in schedule I of the CSA. Today, DEA is providing notice of its intent to publish a new temporary order for MGM-15 and MGM-16 that will maintain the temporary placement of these substances in schedule I of the CSA without change. Separately in this Federal Register, DEA is publishing a notice of intent relating to mitragynine pseudoindoxyl, in response to a letter sent by the Department of Health and Human Services (HHS) dated October 6, 2026. HHS's letter related only to mitragynine pseudoindoxyl. Therefore, DEA is publishing this notice of intent only for the technical and procedural purpose of distinguishing MGM-15 and MGM-16 from mitragynine pseudoindoxyl. When issued, the temporary scheduling order addressing MGM-15 and MGM-16 will continue to impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle these two 7-hydroxymitragynine-related substances. The August 26, 2026 temporary order placing these substances in schedule I of the CSA remains in effect until either it expires or the new temporary order is published and the previous order is withdrawn, whichever occurs first.
91 FR 65381FR Doc. 2026-20942official PDF↗federalregister.gov↗
NoticeJustice DepartmentDrug Enforcement Administration
91 FR 65259FR Doc. 2026-20937official PDF↗federalregister.gov↗
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mcp.downstream.sh as an MCP server in Claude, ChatGPT, or any client that speaks the
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Using the Downstream MCP server at mcp.downstream.sh, call whats_new_since with agency "Drug Enforcement Administration" since 2026-10-14, then summarise what changed and list every deadline it created.
Reaches whats_new_since. The response carries its own citations
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